In rare cases, dark knuckles may be associated with an autoimmune disease such as Sjögren’s syndrome or lupus. PCOS is treatable with drugs and lifestyle changes, such as weight loss and exercise. One of the symptoms may be darkening of the skin, especially in body creases. Polycystic ovary syndrome (PCOS) involves the production of higher-than-normal levels of male hormones in women. This is usually in response to cold temperatures or stress. In Raynaud’s, the blood vessels in your fingers and toes contract and may turn blue and painful. This condition is also linked to Raynaud’s phenomenon, which is often an early symptom of scleroderma. One of the symptoms of scleroderma is a reddening of the skin, including your hands and knuckles. There are many types of scleroderma, and some can be disabling. This leads to the hardening and tightening of the skin and connective tissues. Scleroderma, also called systemic sclerosis, is a rare autoimmune disease that causes an overproduction of collagen. The condition is treatable with drugs to manage symptoms. It usually affects people between 30 and 50 years old. Symptoms can vary, but skin darkening often precedes other symptoms.Ībout 1 in 100,000 people in the United States has Addison’s disease. The darker skin tends to appear near scars or skin creases like the knuckles. It’s caused by the failure of your adrenal glands to produce enough of the steroid hormones known as cortisol and aldosterone.įatigue and darkening in skin color are two common symptoms. Addison’s diseaseĪddison’s disease is a rare condition. There’s no cure for this condition, but symptoms can be treated. Sometimes the rash can appear without any muscle symptoms.ĭermatomyositis most commonly occurs in children between 5 and 15 years old, or adults in their late 40s to early 60s. The rash can be bluish-purple or red in color. The rash can appear on the knuckles as well as on the face, chest, knees, or elbows. Dermatomyositisĭermatomyositis is a rare inflammatory disease that can cause muscle weakness and a skin rash. The knuckle darkening usually disappears once you stop taking the drug. If you’re taking one of these drugs, you may want to discuss alternatives with your doctor. The most common drugs that can cause this include: Some people may develop darkened knuckles because of a drug they’re taking. When B-12 deficiency is treated, the skin on the knuckles will likely return to their normal color. Other symptoms of vitamin B-12 deficiency include:Ī 2017 case study reported that about 10 percent of people with vitamin B-12 deficiency have darkened knuckles. Sometimes it may be the only marker for this deficiency. Vitamin B-12 deficiencyĪccording to a 2016 study, dark knuckles can be an important marker for vitamin B-12 deficiency. It’s thought that high levels of insulin may affect the growth of skin cells. The relationship of dark knuckles and diabetes isn’t fully understood. This is important, because lifestyle changes can help regulate your blood sugar levels and prevent prediabetes from progressing to diabetes. Prediabetes means that your blood sugar levels are higher than normal.Īccording to the Mayo Clinic, prediabetes often has no symptoms, so darkened knuckles can be a warning sign. Prediabetes and diabetesĭark knuckles are most prevalent among people who have diabetes or who have several risk factors for diabetes. But it’s often a symptom or a warning sign of another condition, such as diabetes. It’s thought to be related to mutations in a gene that involves fibroblast growth factor. are African American, Native American, or HispanicĪN is sometimes inherited and can occur in healthy people.According to this study, the condition was more prevalent in Native American, African American, and Hispanic populations.Īnyone can get AN, but you’re at more risk if you: In a 2010 study, AN was diagnosed in 19.6 percent of the study participants, in all age groups. It may also feel itchy or have an odor.ĪN is fairly common. Acanthosis nigricansĪcanthosis nigricans (AN) is a condition that involves darkening and thickening of the skin in one or more areas on the body, including the knuckles. Let’s take a closer look at some of the most common causes. It can also be caused by a vitamin deficiency and certain drugs. Dark knuckles can be a symptom of a variety of health conditions.
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